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Composition/উপাদান:
প্রতি মিলিতে আছে-
wm‡cÖvd¬·vwmb——–200 wg: Mªvg
কুইনোলন আন্টিবায়োটিকঃ
এটি একটি ব্রড স্পেক্ট্রাম ব্যাক্টেরিওসাইড যাতে ৪ কুইনোলন নামে একটি বাইসাইক্লিক কোর গঠন আছে।
ফ্লোরোকুইনোলন হলো এমন একটি ব্যাক্টেরিওসাইড যাতে ফ্লোরিন এটম থাকে এবং গ্রাম পজেটিভ এবং গ্রাম নেগেটিভ উভয় ব্যাকটেরিয়ার বিরুদ্ধে কাজ করে।
কুইনোলন আন্টিবায়োটিক কে কাজের ব্যাপ্তির উপর ভিত্তি করে তিন ভাগে ভাগ করা যায়
প্রথম প্রজন্মঃ
Flumequine , Nalidixic acid
দ্বিতীয় প্রজন্মঃ
Ciprofloxacin, Norfloxacin, Ofloxacin, Enrofloxacin
তৃতীয় প্রজন্মঃ
Levofloxacin, Sparfloxacin
Indications(ব্যবহার ক্ষেত্র):
k^vmbvjxi mgm¨v RwbZ †ivM †hgb: wm.Avi.wW,gvB‡KvcøvR‡gvwmm,AvBGjwU, mvj‡gv‡b‡jvwmm,Kwj‡ewm‡jvwmm,Mvg‡ev‡iv BZ¨vw` রোগের ক্ষেত্রে কার্যকর
Dosages (মাত্রা ও প্রয়োগবিধি):
০.৫ মিলি/ ১ লিটার খাবার পানিতে ৩-৫ দিন
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কার্যপদ্ধতিঃ
লিভোফ্লক্সাসিন ব্যাকটেরিয়া এর DNA gyrase and Topoisomerase IV এনজাইম কে প্রতিরোধ করে এবং ব্যাকটেরিয়া কে ধ্বংস করে ইনফেকশন প্রতিরোধ করতে গুরুত্বপূর্ণ ভুমিকা পালন করে।
প্রত্যাহার কালঃ
সাধারণত লিভোফ্লক্সাসিন ব্যাবহারের দিন থেকে ৭ দিন পর পর্যন্ত এটি ডিম ও মাংসে থাকে। গবেষণাতে দেখা গেছে হৃৎপিণ্ড ও যকৃতের টিস্যু থেকে লিভোফ্লক্সাসিন ব্যাবহারের প্রথম দিন থেকেই Residue মাত্রা কমতে থাকে তবে মাংসে ইহা সাত দিন পর্যন্ত উপস্থিত থাকে। তাই এই সময়টিতে মাংস ও ডিম ব্যাবহারে সতর্ক ভূমিকা পালন করতে হবে।
পোলট্রির শরীরে বিভিন্ন অঙ্গে কুইনোলন এন্টিবায়োটিক এর Antibiotic Residue এর তুলনা মূলক প্রতিচিত্র
Liver > Kidney > Muscle > egg
Liver: Enrofloxacin > Ciprofloxacin > Ofloxacin = Flumequine > Levofloxacin > Norfloxacin
Kidney: Ciprofloxacin > Enrofloxacin > Ofloxacin > Flumequine > Levofloxacin > Norfloxacin
Muscle: Enrofloxacin > Ciprofloxacin > Ofloxacin > Flumequine > Norfloxacin > Levofloxacin
Egg: Ciprofloxacin > Enrofloxacin > Ofloxacin > Levofloxacin > Flumequine > Norfloxacin
কুইনলোনের মাঝে সবচেয়ে বেশি পরিমাণ অ্যান্টিবায়োটিক রেসিডিউ হিসেবে যকৃত ও মাংসে থাকে Enrofloxacin এর রেসিডিউ । অপরদিকে Ciprofloxacin বৃক্ক ও ডিম এ রেসিডিউ হিসেবে থাকে
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